Of the 2200 differentially expressed genes in skeletal muscle identified in women with PCOS (P < 0.05), 57 were regulated in response to electroacupuncture (q < 0.05, Fig. 4a, Supplementary Table S7 (30)), and for 54 of these genes (95%) the changes were directed toward a healthy phenotype as illustrated for CCL2, CYR61, DYRK2, IRS1, LDLR, MSX1, SLC2A3, SORBS1, and SRXN1 (Fig. 5). This evidence concerns the gene IRS1 and polycystic ovary syndrome.