Diabetes mellitus and hypertension are common diseases in the elderly and are proven to be two of the most important risk factors for kidney injury.[30] Renal aging plays as a crucial role in acute kidney injury and CKD, which is proven to be an interconnected syndrome.[31] Naudé et al found that plasma NGAL concentrations were significantly associated with age.[32]. This evidence concerns the gene LCN2 and chronic kidney disease.