Importantly, we did not detect in any LM case any of the mutations in tumor suppressor genes that are frequently mutated in LMS, such as TP53, RB1, PTEN, ATRX, ATM, and ARID1A. 6 This indicates that mutations in these driver genes may be highly specific to malignant tumors such as LMS. Here, TP53 is linked to lymphangioma.