Enhancing brain cholinergic signaling through administering centrally-acting acetylcholinesterase inhibitors such as galantamine also results in suppression of aberrant inflammatory responses through vagus nerve-mediated signaling in mouse models of endotoxemia, colitis and lupus (Pavlov et al., 2009; Ji et al., 2014; Pham et al., 2018). Here, ACHE is linked to systemic lupus erythematosus.