TNF and rheumatoid arthritis: Bioelectronic devices targeting the inflammatory reflex reduce TNF and inflammation in preclinical models of inflammatory disease, and in patients with rheumatoid arthritis and Crohn’s disease (Chavan et al. 2017; Andersson and Tracey 2012a; Levine et al. 2014; Koopman et al. 2016; Bonaz et al. 2016).