Imperfect intensive insulin treatment may also reduce the warning symptoms and hormonal defenses against hypoglycemia leading to defective counterregulation and hypoglycemia unawareness (White et al. 1983; Cryer and Gerich 1985; Amiel et al. 1987; Amiel et al. 1988); thus, intensive treatment may trigger severe hypoglycemia (Gold et al. 1993; Henderson et al. 2003; Lincoln et al. 1996; The Diabetes Control and Complications Trial Research Group 1997). Here, INS is linked to diabetes mellitus.