INS and Insulin resistance: Moreover, recent studies in this area have demonstrated that mice lacking insulin receptors in AgRP neurons (AgRP IR KO mice) exhibited a mild hepatic insulin resistance (Shin et al. 2017; Qatanani and Lazar 2007; Lin et al. 2010; Könner et al. 2007), defined as a reduced ability to suppress hepatic glucose production, while the ability of insulin to suppress adipose tissue lipolysis remained intact (Shin et al. 2017).