Activation of MST1/2 has been associated with the progression of AD, where amyloid precursor protein (APP) promotes the interaction of transcription factor FOXO3a with MST1, triggering Bim (a proapoptotic member of te Bcl-2 family)-mediated neuronal death (Sanphui and Biswas, 2013). The gene discussed is FOXO3; the disease is Alzheimer disease.