With the aim to identify mediators of EWS/FLI1 function, the component of chromatin-activating machinery BRD4 was pharmacologically inhibited in ES leading to the identification of PHF19, a protein associated with PRC2, as a novel EWS-FLI1-regulated gene (Gollavilli et al., 2018). Here, EWSR1 is linked to Ewing sarcoma.