Studies by Kinder and colleagues report that metastatic MDA-MB-231 breast cancer cells increase the production of inflammatory cytokines such as IL-6, monocyte chemoattractant protein-1 (MCP-1), and IL-8 in both, human hFOB 1.19, and murine M3T3-E1 osteoblasts (35). This evidence concerns the gene CCL2 and breast carcinoma.