Somatic mutations of MLH1 (mutL homolog 1), MSH2 (mutS homolog 2), MSH6 (mutS homolog 6), and PMS2 (PMS1 homolog 2, mismatch repair system component) in CRC tissue could be used to screen for Lynch syndrome (9, 10). The gene discussed is MSH6; the disease is colorectal carcinoma.