SPOP and posterior cortical atrophy: For example, we find that: (1) for intermediate- and high-grade PCa, most of the studied aberrations (i.e., ERG fusions, somatic mutations in SPOP, TP53, ATM, and PTEN, CNAs in LCP1 and ERG) affect EAs more than AAs and (2) somatic mutations in ATM consistently impact EAs more over all three grades.