The rather inflammatory polarity of the immune microenvironment in NPM1 mutated AML is further supported by research that revealed that NPM1 mutation generates immunogenic peptides (50), an IFN-γ-driven T cell response (51) and is correlated with B7-H3 and PD-L1 expression (32, 52). This evidence concerns the gene CD276 and acute myeloid leukemia.