As B7 ligands and their counterpart T cell receptors are regarded as indirect indicators of an IFN-driven “inflammatory” microenvironment, we can thus hypothesize that the B7 immune profiling of AML blasts and T cells could serve as a useful biomarker to rapidly discriminate between AMLs with “inflamed” vs. “non-inflamed” microenvironment. This evidence concerns the gene CD80 and acute myeloid leukemia.