Previous research has shown that upregulation of B7 ligands such as programmed death ligand 1 (PD-L1), PD-L2, and B7.2 on AML blasts is inducible by exposure to interferon γ (IFN-γ) (25–27), which indicates an “inflamed” immune profile. This evidence concerns the gene PDCD1LG2 and acute myeloid leukemia.