Out of these, complex karyotype AML-NOS expressed either B7.2 isolated or co-expressed B7.2, ICOS-L, and PD-L1, while normal karyotype AML-NOS also expressed PD-L2, B7-H3, and B7-H4 alongside B7.2, ICOS-L, and PD-L1 (Figure 1B). Here, CD276 is linked to acute myeloid leukemia.