CD4 and acute myeloid leukemia: By contrast, B7-negative AML was characterized by higher percentages of naive CD4+ and CD8+ T cells and lower ICR expression and was more prevalent in AML with t(8,21)(q22;q22) but also in AML harboring the t(9,11)(p21;q23), an entity with rather low immunogenicity, as shown by previous research (53, 54).