CD274 and acute myeloid leukemia: Since the expression of the immune escape PD-1/PD-L1 axis is correlated with an IFN-rich “inflamed” LME (9), it will be a challenge for future studies to demonstrate that the expression of B7 checkpoint ligands could serve as feasible alternative or complementary markers of AML with “inflamed” microenvironment, impacting upon distinctive immunotherapy approaches.