PTCH1 and neoplasm: Also the tumor latency in double-mutant mice, either Ptch1+/−/Btg1+/− or Ptch1+/−/Btg1KO, did not significantly differ from that of control Ptch1+/−/Btg1WT mice (Ptch1+/−/Btg1+/− vs. Ptch1+/−/Btg1WTp = 0.852; Ptch1+/−/Btg1KO vs. Ptch1+/−/Btg1WTp = 0.386; Student's t-test; Table 1).