The mutations of Hspa1l is supposed to be associated with inflammatory bowel disease, an increased risk of male infertility and spontaneous preterm births (Ciftci et al., 2015; Huusko et al., 2018; Kohan, Tabiee & Sepahi, 2019; Takahashi et al., 2017). The gene discussed is HSPA1L; the disease is male infertility.