No significant differences with respect to the number or phenotype of T-regulatory cells or effector T-cells were detected when comparing leukocytes isolated from lymph nodes of mice treated with anti-CD40 or from the anti-CD40 and epacadostat combination treated group, indicating that the main effect of agonistic CD40 mAb and epacadostat on T-cell activation was observed in the tumor microenvironment (Supplementary Fig S6A-E). This evidence concerns the gene CD40 and neoplasm.