IL6 and bone cancer: Zhou et al. (2016) published a review of the regulatory role of IL6 in pathological pain. Based on numerous documents, they stated the essential part for IL6 in pathological types of pain. They investigated the importance of IL6 in the pathological types of pain associated with several diseases such as bone cancer, the peripheral neuropathy due to chemotherapy, and spinal cord and peripheral nerve injuries (Zhou et al., 2016).