NR1H4 and liver cancer: In Gaieb's study, they proved that 5q15 is the specific ligand binding to the nuclear receptor farnesoid X receptor (FXR).30 As reported, FXR can make novel regulatory influence on metabolic homeostasis of nutrients, fats, sugars and proteins by bile acids in liver cells.31 Meanwhile, it has been approved that FXR can functionally prevent liver cancer by protecting tumor suppressor proteins from degradation via C/EBPβ-HDAC1 complexes.