However, ERG nuclear expression (which is correlated to TMPRSS2:ERG rearrangement) is significantly lower in PCa samples for men of Chinese origin than samples from the UK, suggesting that TMPRSS2:ERG rearrangement may not be a suitable biomarker for detecting PCa in Chinese men.29 Currently, the use of this biomarker has not been approved by the FDA. Here, ERG is linked to posterior cortical atrophy.