KLK3 and posterior cortical atrophy: 53 The PBRS also demonstrated improvements when compared to the biomarkers alone in accurately in the AUC curve for all PCa, PCa with a Gleason score ≥ 7, PCa with a clinical stage ≥ T2b, and PCa with D'Amico risk > low. However, this was a retrospective analysis and many men with PSA levels of 4-10 ng/ml refused biopsies and opted for follow-up observation and were underrepresented in this study. As such, while the PBRS shows promise, further investigation is required to validate this model 53.