To gain insight into the mechanisms through which miR-129-2-3p modulates the proliferation and invasion of ICC cells, bioinformatics analysis was performed to predict the putative targets of miR-129-2-3p and found that the 3′-UTR of Wip1 contains a highly conserved binding site for miR-129-2-3p (Figure 3A). The gene discussed is PPM1D; the disease is intrahepatic cholangiocarcinoma.