To further elucidate the target mRNAs of miR-204-5p regulation that contributed to the suppressive role of GC metastasis, complementary sequence of miR-204-5p is identified in the 3'-UTR of Chemokine ligand 12 (CXCL12)/chemokine receptor 4 (CXCR4) mRNA by Targetscan. This evidence concerns the gene CXCR4 and gastric cancer.