MUC16 and cancer: The probably mechanisms are as follows: CA125 can reverse the suppressive effect of Wnt pathway inhibition on cancer cell migration 9, which results in a poor prognosis; CA125 might play a broad role in humoral immune suppression in cancers by direct binding to a subset of tumor-targeting antibodies and blockade of their immune-effector function32; and cancer-derived serum CA125 possesses a unique and distinctive postprandial pattern; thus, postprandial increase in serum CA125 is a surrogate biomarker for early prognostic assessment of OC 9.