HBB and sickle cell disease: The only two variants with “Pathogenic” status were c.20A > T (rs334) in HBB (causes recessive sickle cell disease MIM:603903; carriers are protection from malaria, MIM:611162) and c.1521_1523delCTT (rs1801178) in CFTR [causes recessive cystic fibrosis disease, MIM:219700; hypothesized to be protective from cholera (Rodman and Zamudio, 1991) or tuberculosis (Bosch et al., 2017)].