Noteworthily, all hot subnetworks were significantly overlapped with pathways in cancer (hsa05200), while other enriched pathways included cell-cycle (Vermeulen et al., 2003), ECM-receptor interaction (Lu et al., 2012) and VEGF signaling pathway (Roskoski, 2007), all have been reported to be related with tumor progression. Here, VEGFA is linked to cancer.