Nebor et al. (116) failed to find an association between Duffy phenotype and the clinical severity in a large cohort of SCD patients, but they reported higher plasma IL-8 and RANTES levels in Duffy-positive vs. Duffy-negative patients, suggesting that RBCs can clearly modulate the level of inflammation in SCD. The gene discussed is CCL5; the disease is Schnyder corneal dystrophy.