Collectively, these findings suggest that hemolysis-related products could play a major role in the pathophysiology of several complications in SCD, through their binding to TLR4 and the activation of NF-κB and NLRP3 pathways and the enhanced production of pro-inflammatory cytokines, such as IL1β and IL18 (15). The gene discussed is NLRP3; the disease is Schnyder corneal dystrophy.