In general, H3N2 and H5N1 infection induced IFN-α, TNF-α, MCP-1 (CCL-2), IL-1β, and IL-6 responses in ANP32B+/+ mice were reduced in ANP32B−/− mice, particularly 3 days post infection (Figures 4A–E). The gene discussed is IL1B; the disease is infection.