F2 and cancer: Regarding coagulation-related proteins, this is the first report showing their expression by NKEVs and with regulatory functions, i.e., factors V, VIII, IX, X, and XIII, fibrinogen, prothrombin, anticoagulant antithrombin, protein S, and protein C. In cancer, coagulation facilitates tumor progression through the release of platelet granule contents, inhibition of NK cells, and recruitment of macrophages (54–56).