Based on the relationship among galectins, eosinophils, macrophage polarization, and pathology of schistosomiasis japonica, our data demonstrated that Gal-1, Gal-3, eosinophils, and macrophages play important roles in S. japonicum egg deposition-induced immune response and fibrosis in advanced schistosomiasis japonica mouse model. This evidence concerns the gene LGALS3 and Schistosomiasis japonica.