In the present study, our data demonstrated that both Gal-1 and Gal-3 were significantly increased in the livers, spleens, large intestines, and peritoneal macrophages of S. japonicum-infected mice at 8 weeks p.i., indicating that Gal-1 and Gal-3 play a role in the regulation of egg granuloma pathology during schistosomiasis japonica. This evidence concerns the gene LGALS1 and Schistosomiasis japonica.