Therefore, the purpose of this study was to investigate if normoglycemic, otherwise healthy, young adult Mexican-American males with a first-degree FH+ (1) are more insulin resistant or metabolically inflexible compared to individuals without a family history of type 2 diabetes and (2) are able to achieve exercise-induced improvements in insulin sensitivity, metabolic flexibility, aerobic fitness, body composition, or muscle strength to a similar extent after eight weeks of combined aerobic and resistance exercise training, compared to those without a family history of type 2 diabetes. The gene discussed is INS; the disease is type 2 diabetes mellitus.