AGT and diabetes mellitus: Preclinical evidence for an activated renal RAS in DM is suggested by our and others studies on increased synthesis and urinary secretion of renal angiotensinogen (Zimpelmann et al., 2000; Saito et al., 2009; de Alencar Franco Costa et al., 2015; Lee et al., 2017) (Figure 2 shows urinary angiotensinogen as a potential biomarker).