As aliskiren does not lower blood pressure in hypertensive patients with low PRA (Sealey and Laragh, 2009), Jagadeesh et al. (2012) suggested that “it may be useful to dichotomize RAAS-related pathologic syndromes into ones associated with high renin (some HTN, any HTN after diuretic treatment), where aliskiren appears to be quite effective, and low-renin” (like diabetes), where aliskiren is of uncertain value. Here, S100A6 is linked to hypertensive disorder.