In agreement with our findings, previous studies have shown that the inhibition of 15-PGDH can promote tissue repair and regeneration after bone marrow transplantation, colitis and partial hepatectomy (Zhang et al., 2015), which also indicate that, in addition to alleviating kidney damage, inhibition of 15-PGDH may affect other organs, thereby improving survival rates in mice. Here, HPGD is linked to colitis.