A genotype-phenotype correlation analysis revealed that EGFR10-11 and EGFR2-5 mutations are associated with different phenotypes, with EGFR10–11 mutants usually presenting with milder cognitive deficits, lower volume of lacunar infarcts, and higher volume of white matter hyperintensities at MRI, suggesting different pathological processes related to different NOTCH3 mutations (Joutel, 2011). The gene discussed is NOTCH3; the disease is Cognitive impairment.