Furthermore, these studies found that when SS patients were stratified based on the presence of anti-Ro/SSA autoantibodies, the increased expression of P2X7R and NLRP3 inflammasome components was even more pronounced in seropositive cohorts compared to seronegative cohorts (Baldini et al., 2013, 2017). The gene discussed is NLRP3; the disease is synovial sarcoma.