Interestingly, LT-α levels are increased in the saliva, serum and salivary glands of SS patients, as compared to healthy individuals (Shen et al., 2010; Teos et al., 2015), and blockade of the LT-α receptor has been shown to reduce sialadenitis and improve the secretory function of the salivary gland in the IL-14αTG and NOD mouse models of SS (Gatumu et al., 2009; Shen et al., 2013). Here, LTA is linked to sialadenitis.