Our group reported that in vivo inhibition of P2X7Rs using the competitive antagonist A-438079 significantly reduced sialadenitis and improved carbachol-induced saliva flow in the NOD.H-2h4, CD28–/–, IFNγ–/– murine model of SS-like salivary gland autoimmune exocrinopathy (Khalafalla M.G. et al., 2017). The gene discussed is IFNG; the disease is sialadenitis.