Previous studies have demonstrated that the P2Y2R is upregulated in major salivary glands of several mouse models of SS, including NOD.B10 (Schrader et al., 2005), IL-14α transgenic (IL-14αTG) (Woods et al., 2018) and C57BL/6-NOD.Aec1Aec2 mice (unpublished observations). The gene discussed is P2RY2; the disease is synovial sarcoma.