Additionally, SS patients produce high levels of immunoglobulins and autoantibodies besides anti-Ro/SSA and anti-La/SSB (Nardi et al., 2006; Suresh et al., 2015), including anti-α-fodrin (Watanabe et al., 1999; Miyazaki et al., 2005), RF (rheumatoid factor) (Müller et al., 1989; Huo et al., 2010) and other autoantibodies (Ramos-Casals et al., 2006; Shen et al., 2014; Suresh et al., 2015) that have been previously reported to activate intrinsic and extrinsic apoptotic pathways in salivary gland cells (Sisto et al., 2006; Lisi et al., 2007). This evidence concerns the gene TRIM21 and synovial sarcoma.