NLRP3 and synovial sarcoma: Previous studies have demonstrated that the expression of P2X7R, caspase-1, IL-1β, IL-18 and components of the NLRP3 inflammasome multiprotein complex are significantly increased in labial salivary gland biopsies from SS patients, which positively correlates with salivary gland focus score (# of mononuclear cell foci/4 mm2 tissue area) (Baldini et al., 2013, 2017).