Clinical classification criteria for primary SS (pSS) in the absence of other autoimmune diseases include the presence in blood serum of anti-Ro/SSA and anti-La/SSB autoantibodies to their intracellular antigens, increased corneal staining using fluorescein dye (ocular staining score ≥ 5), decreased tear (Schirmer’s test ≤ 1 mm/min) and saliva (≤ 0.1 ml/min) flow rates and the presence of focal lymphocytic sialadenitis (focus score ≥ 1 foci/4 mm2) in minor salivary gland biopsies (Shiboski et al., 2017). Here, CALR is linked to autoimmune disease.