Additionally, attenuated sialadenitis following P2Y2R deletion correlated with significantly reduced levels of LT-α in salivary gland epithelial cells and infiltrating immune cells, suggesting that P2Y2R-mediated LT-α expression contributes to salivary gland inflammation in IL-14αTG mice (Woods et al., 2018). The gene discussed is P2RY2; the disease is sialadenitis.