To identify new CUGBP1 targets and characterize the global impact of the novel RNA decoy mechanism of miR-574-5p and CUGBP1, with the aim of demonstrating the specificity of the biomarker miR-574-5p, we applied a tandem mass tag (TMT)-based proteomics approach in A549 lung cancer cells. This evidence concerns the gene CELF1 and lung cancer.