However, with the binary logistic regression analysis of the interaction between the serum lipids and APOE genotype on cognitive impairment, we found that the interaction between low HDL and APOE ε4 status was positively correlated with cognitive impairment (Wald’s χ2 = 4.269, df = 1, OR = 20.094, 95% CI = 1.167–346.056, p = 0.039), and the interaction between other serum lipid parameters (high TG, high TC, and high LDL levels) and APOE ε4 status had no significant effect on cognitive impairment (Table 2, Model 3). The gene discussed is APOE; the disease is Cognitive impairment.