Univariate analysis showed that compared with APOE ε4 non-carriers, serum TC, TG, and LDL levels were higher and HDL levels were lower in APOE ε4 carriers [TC: 5.36 ± 0.94 mmol/L vs. 5.15 ± 0.99 mmol/L, df = 1,271, p = 0.008; TG: 1.48 (1.09, 2.15) mmol/L vs. 1.29 (0.96, 1.80) mmol/L, p < 0.001; LDL: 2.82 ± 0.62 mmol/L vs. 2.61 ± 0.66 mmol/L, df = 1,271, p < 0.001; HDL: 1.53 ± 0.32 mmol/L vs. 1.60 ± 0.34 mmol/L, df = 1,271, p = 0.007], and the prevalence of dyslipidemia was also significantly higher in APOE ε4 carriers [132 (69.8%) vs. 622 (57.4%), df = 1, p = 0.001]. The gene discussed is APOE; the disease is metabolic syndrome.