In addition to being an incretin hormone, GIP signaling and GIPR have been shown to play a role in diet-induced obesity,98 adipokine secretion,99 lipoprotein lipase activity, and TG accumulation.100 Degradation of significant amounts of GIP by DPP4 occurs within in the gut by both endothelial and immune cell populations.30 The gene discussed is DPP4; the disease is Obesity.