However, in rare cases such as large granular lymphocytic leukaemia, aggressive natural killer cell leukaemia and inflammatory hepatocellular adenocarcinoma, activating STAT3 mutations have been found in the Src homology 2 (SH2) domain near the Y705 phosphorylation site that result in a constitutively activated STAT3 [6–10]. The gene discussed is STAT3; the disease is aggressive NK-cell leukemia.