A total of 136 DO terms were enriched for genes in the green module (up-regulated with TNFa), with infectious, respiratory, skin, connective tissue, and hypersensitivity reaction diseases being among the most statistically significant, but several autoimmune diseases, including systemic lupus erythematosus, rheumatoid arthritis, Graves’ disease, psoriasis, and multiple sclerosis were also enriched for green module genes, as were diabetes, coronary artery disease, and atherosclerosis (Fig 3, S1 Fig, and S4 File). Here, TNF is linked to multiple sclerosis.