TNF and psoriasis: These included genes such as chemokines CXCL1, CXCL10 and CXCL8 and genes associated with autoimmune diseases such as HLA-C, DDX58, IL4, NFKBIA and TNFAIP3 which are associated with psoriasis susceptibility.[18] Moreover, NFKB1 from this module mediates Th1/Th17 activation in the pathogenesis of psoriasis and probably other autoimmune diseases.[19] Green genes also had more DMRs, either in the gene bodies or in GH elements mapped to the genes, suggesting that TNFa stimulation causes more long-lasting changes to gene expression to genes in the green set than to other sets.