Moreover, with their potential for human infection, SL-CoVs, including WIV1, Rs3367 and RsSHC014, the fusion process of which is mediated by S protein, could also be significantly prevented by EK1C4 with IC50 ranging from 4.3 to 8.1 nM, as well as EK1 with IC50 ranging from 237.0 to 279.6 nM (Fig. 5f–h). The gene discussed is PROS1; the disease is infection.