The overexpression of HNF4α and the TGF-β1-inhibitory Smad7 suppressed tumorigenicity of HCC cells in a CD147-knockdown background.72 This study showed a role of TGF-β1 and CD147 in a positive relationship to promote cancer stemness and the plasticity in EMT in HCC. This evidence concerns the gene TGFB1 and hepatocellular carcinoma.