HCC cells upregulated their expression of C-C chemokine receptor type 2 (CCR2) and C-X-C motif chemokine receptor 1 (CXCR1), and also had EpCAM expression,92 indicating that peritumoural fibroblasts could potentially recruit and maintain CSCs. The gene discussed is CXCR1; the disease is hepatocellular carcinoma.