ANXA3 and hepatocellular carcinoma: These cells and samples are also enriched in CD133, which was previously identified to mark a subset of CSCs in HCC, implicating ANXA3 in the control of stemness and resistance towards sorafenib and regorafenib.109,110 ANXA3 activates autophagy for cell survival and specifically suppresses protein kinase Cδ/p38-mediated apoptosis induced by stress.