Interestingly, the knockdown of TAZ attenuated growth under normal conditions but induced a compensatory upregulation of YAP together with an increase in the expression of the CSC marker CD90 in the presence of 5-fluorouracil, which contributes to chemoresistance.67 This result suggests that Hippo signalling might play an oncogenic role in HCC by conferring LCSC properties, and notably, that, when targeting Hippo signalling in HCC cells, simultaneous inhibition of TAZ and YAP should be considered to avoid potential compensatory actions. The gene discussed is THY1; the disease is hepatocellular carcinoma.