CCL20 and hepatocellular carcinoma: A tumour-promoting role for CCL20-induced B cell recruitment was subsequently confirmed.99 These results suggest that chemokines released by HCC cells can help to recruit tumour-promoting immune cells to promote angiogenesis and tumour initiation in HCC but whether angiogenesis and tumour initiation essentially occur in sequential order and whether the recruited B cells enhance stemness genes/markers in HCC cells in the above mouse models needs further investigation.