For example, Lup-20(29)-en-3b-ol (Lupeol), a triterpene derived from fruits and vegetables, can suppress CD133+ LCSC populations and sensitise HCC cells to chemotherapeutic agents by modulating PTEN.120 In addition, baicalein, a type of flavonoid isolated from plant roots, can inhibit SAR1B GTPase, which is required for autophagy, to specifically sensitise LCSCs, but not normal cells, to mTORC1 inhibition.121. This evidence concerns the gene PROM1 and hepatocellular carcinoma.