Specifically, miR-130b and miR-1246p were overexpressed in HCC.55,56 miR-130b targets and downregulates the expression of tumour protein 53-induced nuclear protein 1, a pro-apoptotic tumour suppressor that triggers autophagy;55 while miR-1246p targets and downregulates the expression of AXIN2 and GSK-3β to promote Wnt signalling.56 By contrast, miR-142-3p directly targets and downregulates CD133 expression; miR-142-3p was found to be underexpressed in a CD133+ CSC population, and its re-expression antagonised CD133-mediated cancer stemness properties.57 This evidence concerns the gene PROM1 and hepatocellular carcinoma.