Cripto-1, a member of the epidermal growth factor-CFC family of proteins, is a protein overexpressed in HCC and associated with poorer overall and disease-free survival as it conferred stemness phenotypes in HCC cells by binding to Dvl3 protein and maintaining its stability,35 which promoted Wnt/β-catenin signalling.32 This evidence concerns the gene EGF and hepatocellular carcinoma.