YY1 and lung cancer: In addition, overexpression of YY1 resulted in a significant decrease in expression of DCBLD1 in a dose–response manner in lung cancer cell line A549 (with C/T genotype at rs17079281), but overexpression YY1 in lung cancer cell line NCI-H1299 (with C/C genotype at rs17079281) did not have the same effect (Fig. 2d).