Otulin deletion by tamoxifen administration resulted in weight loss in Otulin-KOChim mice (Fig. 1b), which was accompanied by highly icteric serum (Fig. 1c) with a ~12-fold increase in the level of the haem metabolite bilirubin (Fig. 1d), indicating potential liver failure in Otulin-KOChim mice. Here, OTULIN is linked to Hepatic failure.