CHRNA4 and neuroblastoma: As a defined in vitro neuronal model expressing one of the prominent receptor targets for Aβ, namely high affinity α4β2-type nicotinic receptors, which sensitize the cells to Aβ toxicity14, neuroblastoma hybrid rodent NG108-15 cells exclusively expressing mouse α4β2-nAChRs (nAChR-NG108-15) were treated daily with 100 nM soluble oligomeric Aβ1–42 as compared to vehicle-treated, receptor-expressing controls.