TREM2 and Alzheimer disease: The genes and pathways identified here in our acute Aβ neurotoxicity models are also in contrast to genes strongly correlated with late-onset AD, including apolipoprotein E (APOE), triggering receptor expressed on myeloid cells 2 (TREM2) and cluster of differentiation 33 (CD33)21–24 among others, suggesting differences in gene regulation with early rises in Aβ in brain (prodromic period) as compared to AD.