We treated SB-3123p melanoma cells with either JQ1, BI-2536, Fenobam or PHA-793887 and found that the 4 compounds up-regulated the transcription of MITF and its target genes, DCT, Tyrp, Melan A and Pmel-1 in a dose dependent fashion as determined by qPCR (Fig. 3D). The gene discussed is TYRP1; the disease is melanoma.