Recently, we furthered the understanding in MM, where we showed that oncogenic NF-κB signaling mediates cancer cell survival by upregulating GADD45B, which, in turn, suppresses apoptosis ensuing from JNK/MAPK-pathway activation by inhibiting MKK7 (Fig. 1)30–32. The gene discussed is NFKB1; the disease is Miyoshi myopathy.