Recently, Yang et al. demonstrated that chloroquine (CQ), an autophagic blocker, triggers the activation of NF-κΒ and its target genes, such as hypoxia-inducible factor 1-alpha (HIF-1α), interleukin-8 (IL-8) and antiapoptotic genes like BCL-2 and BCL-XL, in both squamous cell carcinoma and melanoma cells. The gene discussed is CXCL8; the disease is melanoma.