In accordance with the relevance of TME-associated autophagy in cancer, Martinez-Outschoorn et al. showed that, under oxidative stress and hypoxia, cancer cells induced autophagic degradation of caveolin 1 (Cav-1) in cancer-associated fibroblasts (CAFs) by upregulating NF-κB and HIF-1. The gene discussed is CAV1; the disease is cancer.