In according with the antitumoral function of necroptosis, Koppe and colleagues demonstrated that IKKα and IKKβ deletion in LPC (IKKα/βLPC-KO) induced cholestasis and, at the same time, inhibited HCC, due to increased intrahepatic necrosis and reduced compensatory proliferation in vivo. This evidence concerns the gene CHUK and hepatocellular carcinoma.