In a similar manner, when BMAL1 was ectopically expressed via adenovirus in U87MG cells, the migration and invasion of cells declined in the wound healing and Matrigel assays through the downregulation of p-AKT and MMP-9 signaling pathways, which are known to coordinate the migration and invasion of tumor cells (Figure 6). The gene discussed is BMAL1; the disease is neoplasm.