For this purpose, IL10−/− mice were subjected to broad-spectrum antibiotic treatment starting immediately after weaning in order to deplete the commensal gut microbiota and, hence, to abrogate physiological CR preventing C. jejuni infection and furthermore, in order to eliminate potential colitogenic stimuli from the commensal gut microbiota, leading to chronic colitis in IL10−/− mice after 3 months or more [47,48,50]. This evidence concerns the gene IL10 and Chronic colitis.