To date, it has been reported that fish cytokines such as IL-6 [22], IL-8 [23,24,25], IL-2 [24,26], IL-1β [24,25,27], IL-15, IL-17 [24], TNFα, granulocyte colony-stimulating factors (G-CSF) [25], IL12 [28], chemokine (C-C motif) ligand 3 (CCL3), CCL4, CCL19, CCL21 [29], and IFNγ [30] can be applied as promising molecular adjuvants for DNA or recombinant subunit vaccines against particular viral or bacterial infections. Here, CCL3 is linked to bacterial infectious disease.