Since it is known that a pro-inflammatory pressure can contribute to the recruitment and activation of anti-tumor immune cells [18,19,20], we assessed whether CD68HighHIF1AHigh enriched tumors presented an increased expression of markers of natural killer (NK) cells (NCAM1, within the CD3DLow population), cytotoxic T-cells (CD8A, within the GZMBHigh population), and Th1 cells (TBX21, within the IFNGHigh population). Here, CD8A is linked to neoplasm.