The constitutive DNA binding and transactivation activities of p65/p50 heterodimers observed in pancreatic cancer cells are positively regulated by both GSK3α and β, since GSK3 inhibition (including paralog-specific siRNA) results in reduced p65 phosphorylation, DNA binding, and NF-κB-dependent gene expression, while p50 homodimers seem to be unaffected. Here, RELA is linked to pancreatic neoplasm.