Decreased GSK3β-Ser9 phosphorylation, increased TNF, IL-6, COX-2, and iNOS expression, and the abolishment of these effects by SB216763 can also be observed in the hippocampi of rats with diabetes induced by a combination of a high-fat diet and low streptozotocin concentrations [156]. This evidence concerns the gene GSK3B and diabetes mellitus.