PTPRO and Fulminant hepatitis: In comparison to WT mice, protein tyrosine phosphatase receptor type O (PTPRO) KO mice are characterized by significantly attenuated inflammation (i.e., decreased amounts of TNF, IL-1β, IL-6, IFN-γ, CCL2, 3, and CXCL10; reduced numbers of infiltrating immune cells in the liver) following the induction of fulminant hepatitis using Concanavalin A injection.